Ecosystems in the North Pacific have been significantly impacted by climate change and human activities. For over 30 years, PICES has established an international scientific network and conducted numerous projects to enhance our understanding of how North Pacific ecosystems respond to such impacts. However, with the recent intensification of climate change and the increase in unpredictable extreme events, previously held understandings may no longer be valid. There is a pressing need for discussions on integrating the latest scientific findings and technologies (e.g., artificial intelligence, remote sensing, biotechnology) by experts from diverse fields, including marine science, environmental conservation, engineering, economics, and social science. Equally important is the collaboration with local fishing communities, policymakers, NGOs, and other stakeholders to explore practical applications of scientific knowledge. PICES-2025 will serve as a crucial platform for exploring innovative approaches to understanding North Pacific ecosystems, helping to chart a path toward climate resilience and sustainable development. Contributions from experienced specialists, as well as groundbreaking ideas from Early and mid-Career Ocean Professionals, are highly encouraged.